Depay’s brutal strike counterbalanced Inigo Martinez’s going opener after Athletic Bilbao had ruled.
The two sides hit the crossbar and left behind various opportunities to guarantee each of the three focuses.
Barca protector Eric Garcia was shipped off in injury time for fouling Nico Williams when clean through.
There is no question Ronald Koeman’s side are on the move – the deficiency of Lionel Messi leaving them looking for another charm and attempting to discover better approaches to win.
In any case, in Depay they might have another legend. He scored a rankling first objective for the club and might have scored a victor, just to drag wide late on.
Bilbao had detected shortcoming and attacked their famous guests from the start up.
Inaki Williams threatened an anxious looking Barca backline and strike accomplice Ohian Sancet hit the crossbar with a skilful turn and shot.
Gerard Pique limped off for Koeman’s side halfway through the main half and substitution Ronald Araujo had a tremendous objective refused for a foul by Martin Braithwaite.
Frenkie de Jong’s brash chip nearly evened out before Depay’s strike – yet Koeman faces protective issues for the following week’s home match with Getafe after Garcia pulled down Williams in stoppage time and was shipped off.
Title equals Real Madrid and Atletico Madrid will get the opportunity to jump Barcelona should they dominate their matches on Sunday.